Which stage of the HIV lifecycle involves the virus attaching to the host cell membrane?
Binding
Integration
Fusion
Reverse Transcription
The Correct Answer is A
A. Binding is the initial step where the HIV virus attaches to the CD4 receptor on the host cell's surface. This interaction is crucial for the subsequent entry of the virus into the host cell.
B. Integration occurs later in the lifecycle, after the virus has entered the host cell and its RNA is converted to DNA.
C. Fusion refers to the process where the viral envelope fuses with the host cell membrane to allow entry into the cell, which follows the binding stage.
D. Reverse Transcription is the process of converting viral RNA into DNA after the virus has entered the host cell, and is not involved in the attachment phase.
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Correct Answer is B
Explanation
A. Metabolic alkalosis is characterized by an increased pH and increased HCO3 levels, which does not fit the provided values.
B. The low HCO3 of 18 mEq indicates a metabolic acidosis, as the body is unable to retain enough bicarbonate to balance the acid levels, and the pH is also low at 7.30, confirming acidosis.
C. Respiratory alkalosis would show a high pH and low PaCO2, which is not the case here.
D. Respiratory acidosis would be indicated by a high PaCO2 and a low pH, but the HCO3 level is low, indicating a metabolic issue rather than a respiratory one.
Correct Answer is B
Explanation
A. In the assembly stage, other proteins and enzymes are involved in the packaging of viral components into new virions, not integrase.
B. During the integration stage, integrase is essential as it inserts the newly formed viral DNA into the host's genome, enabling the virus to utilize the host's cellular machinery for replication.
C. Integrase does not participate in the entry stage; this stage is facilitated by other proteins that aid in the fusion of the virus with the host cell membrane.
D. Integrase is not involved in reverse transcription; that process is facilitated by the enzyme reverse transcriptase, which converts viral RNA into DNA.