Which stage of the HIV lifecycle involves the virus attaching to the host cell membrane?
Binding
Integration
Fusion
Reverse Transcription
The Correct Answer is A
A. Binding is the initial step where the HIV virus attaches to the CD4 receptor on the host cell's surface. This interaction is crucial for the subsequent entry of the virus into the host cell.
B. Integration occurs later in the lifecycle, after the virus has entered the host cell and its RNA is converted to DNA.
C. Fusion refers to the process where the viral envelope fuses with the host cell membrane to allow entry into the cell, which follows the binding stage.
D. Reverse Transcription is the process of converting viral RNA into DNA after the virus has entered the host cell, and is not involved in the attachment phase.
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Correct Answer is B
Explanation
A. Respiratory alkalosis is characterized by a high pH and low PaCO2, which is not evident in this scenario where the pH is low and PaCO2 is elevated.
B. The low pH of 7.3 indicates acidemia, and the elevated PaCO2 of 50 mm Hg suggests respiratory acidosis, where the body is retaining carbon dioxide, leading to an increase in acidity.
C. Metabolic acidosis would present with a low pH and a normal or decreased PaCO2, which is not the case here since the PaCO2 is elevated.
D. Metabolic alkalosis would show a high pH and elevated HCO3 levels, which is not consistent with the given ABG results.
Correct Answer is C
Explanation
A. Fusion Inhibitors work by preventing the virus from entering the host's cells but do not inhibit RNA from forming DNA.
B. Integrase Inhibitors block the integration of viral DNA into the host's DNA but do not directly inhibit the reverse transcription process.
C. Nucleoside Reverse Transcriptase Inhibitors (NRTIs) inhibit reverse transcriptase, the enzyme responsible for converting viral RNA into DNA, thus directly targeting this crucial stage of the HIV lifecycle.
D. Protease Inhibitors inhibit the protease enzyme involved in the maturation of the virus but do not affect the reverse transcription process.