Which class of antiretroviral drugs targets the stage of the HIV lifecycle by inhibiting RNA from forming DNA?
Fusion Inhibitors
Integrase Inhibitors
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Protease Inhibitors
The Correct Answer is C
A. Fusion Inhibitors work by preventing the virus from entering the host's cells but do not inhibit RNA from forming DNA.
B. Integrase Inhibitors block the integration of viral DNA into the host's DNA but do not directly inhibit the reverse transcription process.
C. Nucleoside Reverse Transcriptase Inhibitors (NRTIs) inhibit reverse transcriptase, the enzyme responsible for converting viral RNA into DNA, thus directly targeting this crucial stage of the HIV lifecycle.
D. Protease Inhibitors inhibit the protease enzyme involved in the maturation of the virus but do not affect the reverse transcription process.
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Correct Answer is D
Explanation
A. The conversion of RNA into DNA is a critical step in the HIV lifecycle, but it does not directly lead to opportunistic infections; instead, it allows the virus to integrate into the host’s genome.
B. Having reverse transcriptase enzyme is a characteristic of retroviruses like HIV that facilitates replication, but it does not cause opportunistic infections directly.
C. HIV containing a single strand of genetic material is a feature of its classification as a retrovirus but is not related to the risk of opportunistic infections.
D. The ability of HIV to target and destroy CD4 lymphocytes is the key reason for opportunistic infections. CD4 cells are crucial for the immune response, and their depletion leads to immunosuppression, making the client susceptible to infections that would not typically affect an individual with a healthy immune system.
Correct Answer is B
Explanation
A. In the assembly stage, other proteins and enzymes are involved in the packaging of viral components into new virions, not integrase.
B. During the integration stage, integrase is essential as it inserts the newly formed viral DNA into the host's genome, enabling the virus to utilize the host's cellular machinery for replication.
C. Integrase does not participate in the entry stage; this stage is facilitated by other proteins that aid in the fusion of the virus with the host cell membrane.
D. Integrase is not involved in reverse transcription; that process is facilitated by the enzyme reverse transcriptase, which converts viral RNA into DNA.