Which class of antiretroviral drugs targets the stage of the HIV lifecycle by inhibiting RNA from forming DNA?
Fusion Inhibitors
Integrase Inhibitors
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Protease Inhibitors
The Correct Answer is C
A. Fusion Inhibitors work by preventing the virus from entering the host's cells but do not inhibit RNA from forming DNA.
B. Integrase Inhibitors block the integration of viral DNA into the host's DNA but do not directly inhibit the reverse transcription process.
C. Nucleoside Reverse Transcriptase Inhibitors (NRTIs) inhibit reverse transcriptase, the enzyme responsible for converting viral RNA into DNA, thus directly targeting this crucial stage of the HIV lifecycle.
D. Protease Inhibitors inhibit the protease enzyme involved in the maturation of the virus but do not affect the reverse transcription process.
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Correct Answer is A
Explanation
A. Binding is the initial step where the HIV virus attaches to the CD4 receptor on the host cell's surface. This interaction is crucial for the subsequent entry of the virus into the host cell.
B. Integration occurs later in the lifecycle, after the virus has entered the host cell and its RNA is converted to DNA.
C. Fusion refers to the process where the viral envelope fuses with the host cell membrane to allow entry into the cell, which follows the binding stage.
D. Reverse Transcription is the process of converting viral RNA into DNA after the virus has entered the host cell, and is not involved in the attachment phase.
Correct Answer is A
Explanation
A. Administering hypertonic saline (3% NaCl) is appropriate for treating severe hyponatremia, as it helps to raise sodium levels safely. Restricting water intake is also necessary to prevent further dilution of sodium.
B. Fluid restriction with a loop diuretic may not be effective in this scenario and can worsen the hyponatremia by causing further fluid loss without addressing the sodium levels.
C. Isotonic saline is not indicated for correcting severe hyponatremia, and encouraging oral fluid intake could exacerbate the condition.
D. Increasing oral sodium intake is not sufficient for immediate correction of severe hyponatremia and does not address the acute nature of the client’s symptoms.