What is the major reason that monoamine oxidase inhibitors (MAOIs) are rarely used in clinical practice today?
They are under a scheduled drug classification.
They are ineffective in treating depression or anxiety disorders.
They can cause gastrointestinal (GI) bleeding and esophageal varices.
They may cause dangerous interactions with some foods and drugs.
The Correct Answer is D
A. While MAOIs may have some regulatory considerations, they are not classified under a scheduled drug classification like controlled substances.
B. MAOIs are effective in treating depression and anxiety disorders, which is not the reason for their limited use.
C. Although MAOIs can have some side effects, they are more notably associated with dietary and drug interactions rather than causing GI bleeding or esophageal varices.
D. MAOIs can cause dangerous interactions with foods that contain tyramine (like aged cheeses and fermented products) and certain medications, leading to hypertensive crises, making their use cautious and limiting in clinical practice.
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Correct Answer is C
Explanation
A. This insulin does not peak like short-acting insulin; glargine provides a consistent release of insulin without a peak effect.
B. Long-acting insulin is not meant to be taken with meals, as it provides basal control and is typically taken once daily, not with each meal.
C. This statement is correct; glargine provides a steady level of insulin over 24 hours, helping to maintain consistent blood glucose levels throughout the day and night.
D. Long-acting insulin is usually administered once daily, so stating that it must be given three times a day is incorrect.
Correct Answer is A
Explanation
A. Nitroglycerin is contraindicated with erectile dysfunction medications such as sildenafil (Viagra) because both can cause significant drops in blood pressure when used together, potentially leading to severe cardiovascular complications.
B. Furosemide is a diuretic and does not have a direct contraindication with erectile dysfunction medications, although it may contribute to electrolyte imbalances.
C. Verapamil is a calcium channel blocker that does not directly contraindicate the use of erectile dysfunction medications but should be monitored for potential interactions affecting heart rate and blood pressure.
D. Acetaminophen is a pain reliever and does not pose a contraindication for erectile dysfunction medications.