What is the major reason that monoamine oxidase inhibitors (MAOIs) are rarely used in clinical practice today?
They are under a scheduled drug classification.
They are ineffective in treating depression or anxiety disorders.
They can cause gastrointestinal (GI) bleeding and esophageal varices.
They may cause dangerous interactions with some foods and drugs.
The Correct Answer is D
A. While MAOIs may have some regulatory considerations, they are not classified under a scheduled drug classification like controlled substances.
B. MAOIs are effective in treating depression and anxiety disorders, which is not the reason for their limited use.
C. Although MAOIs can have some side effects, they are more notably associated with dietary and drug interactions rather than causing GI bleeding or esophageal varices.
D. MAOIs can cause dangerous interactions with foods that contain tyramine (like aged cheeses and fermented products) and certain medications, leading to hypertensive crises, making their use cautious and limiting in clinical practice.
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Correct Answer is A
Explanation
A. Phenylephrine is a decongestant that can raise blood pressure, making it contraindicated for individuals with hypertension. Advising a patient with hypertension to avoid phenylephrine is essential to prevent potential cardiovascular complications.
B. While patients with diabetes should be cautious about certain medications, phenylephrine is not specifically contraindicated in this condition.
C. A 17-year-old female with an upper respiratory infection typically does not have contraindications for phenylephrine unless there are underlying conditions not mentioned.
D. Gout does not have a direct contraindication for phenylephrine use, so the patient may not need to avoid it unless other health issues are present.
Correct Answer is A
Explanation
A. A return to normal respiratory rate, rhythm, and depth is correct because opioid antagonists, such as naloxone, are primarily used to reverse the respiratory depression caused by opioid overdose.
B. Management of alcohol withdrawal symptoms is incorrect; opioid antagonists do not address alcohol withdrawal.
C. A reduction in the client's rating of their pain is incorrect; opioid antagonists counteract the effects of opioids, which can result in increased pain levels rather than reduction.
D. Alertness and improve memory function is incorrect; while opioid antagonists may improve alertness by reversing sedation, the primary goal focuses on restoring respiratory function.