What is the major reason that monoamine oxidase inhibitors (MAOIs) are rarely used in clinical practice today?
They are under a scheduled drug classification.
They are ineffective in treating depression or anxiety disorders.
They can cause gastrointestinal (GI) bleeding and esophageal varices.
They may cause dangerous interactions with some foods and drugs.
The Correct Answer is D
A. While MAOIs may have some regulatory considerations, they are not classified under a scheduled drug classification like controlled substances.
B. MAOIs are effective in treating depression and anxiety disorders, which is not the reason for their limited use.
C. Although MAOIs can have some side effects, they are more notably associated with dietary and drug interactions rather than causing GI bleeding or esophageal varices.
D. MAOIs can cause dangerous interactions with foods that contain tyramine (like aged cheeses and fermented products) and certain medications, leading to hypertensive crises, making their use cautious and limiting in clinical practice.
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Correct Answer is A
Explanation
A. Confirming that the medication prescribed is the drug of choice for the specific microorganism is crucial in ensuring effective treatment, as the right drug will target the identified infection.
B. Teaching the client that significant adverse effects are expected and must be endured is not a supportive approach; the focus should be on managing and minimizing adverse effects rather than accepting them.
C. Administering antihistamines may not be relevant for all patients undergoing anti-infective treatment and is not a primary strategy for ensuring treatment success.
D. Monitoring for signs of arrhythmias or cardiac ischemia is not directly related to ensuring the success of anti-infective treatment; it may be necessary for certain medications but does not address the effectiveness of anti-infectives specifically.
Correct Answer is D
Explanation
A. Nitrates do not share a cross-sensitivity with penicillin and are safe to use in this client.
B. Tetracycline is a different class of antibiotics and does not have cross-sensitivity with penicillin.
C. Aminoglycosides also do not have cross-sensitivity with penicillin and can be safely administered.
D. Cephalosporins are structurally related to penicillin and have a risk of cross-sensitivity; thus, they should not be given to a client with a history of anaphylaxis to penicillin.