What adverse reaction does the nurse anticipate if a client takes nitroglycerin with sildenafil?
Hypotension
Bradycardia
Chest pain
Nausea
The Correct Answer is A
A. The combination of nitroglycerin and sildenafil can lead to severe hypotension due to the vasodilatory effects of both medications. This is the most critical adverse reaction the nurse should anticipate.
B. Bradycardia is not a direct effect of this combination; rather, hypotension is a more significant concern.
C. Chest pain may occur if hypotension leads to inadequate perfusion, but it is not a direct adverse effect of the drug interaction.
D. Nausea can occur with various medications, but it is not specifically linked to the interaction between nitroglycerin and sildenafil.
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Correct Answer is C
Explanation
A. Hypertension can affect drug distribution to some extent due to altered perfusion but is not the most significant factor impacting distribution, especially for a local condition like cellulitis.
B. Liver dysfunction primarily affects the metabolism and clearance of drugs rather than their distribution, although it may indirectly influence distribution by altering protein binding.
C. Peripheral vascular disease significantly impacts blood flow to the extremities, which can hinder the distribution of the antibiotic to the affected area (the left leg) where the cellulitis is present, leading to reduced drug efficacy.
D. Diverticulitis disease primarily affects the gastrointestinal system and would not directly influence the distribution of an antibiotic used to treat cellulitis in the leg.
Correct Answer is D
Explanation
A. Sodium levels are important to monitor, but they are not the primary concern with furosemide treatment.
B. Bone marrow function is not a direct concern related to furosemide therapy.
C. Calcium levels are less critical compared to potassium when monitoring a client on furosemide.
D. Potassium levels are correct because furosemide is a loop diuretic that can lead to significant potassium loss, putting the client at risk for hypokalemia, which can have serious cardiac implications.