What adverse reaction does the nurse anticipate if a client takes nitroglycerin with sildenafil?
Hypotension
Bradycardia
Chest pain
Nausea
The Correct Answer is A
A. The combination of nitroglycerin and sildenafil can lead to severe hypotension due to the vasodilatory effects of both medications. This is the most critical adverse reaction the nurse should anticipate.
B. Bradycardia is not a direct effect of this combination; rather, hypotension is a more significant concern.
C. Chest pain may occur if hypotension leads to inadequate perfusion, but it is not a direct adverse effect of the drug interaction.
D. Nausea can occur with various medications, but it is not specifically linked to the interaction between nitroglycerin and sildenafil.
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Correct Answer is B
Explanation
A. Hypertension is not a common side effect of antiplatelet therapy; rather, it may be managed or monitored during treatment.
B. Gastrointestinal bleeding is a well-documented side effect of antiplatelet medications like clopidogrel, as they inhibit platelet aggregation and can increase bleeding risk.
C. Hyperglycemia is not typically associated with antiplatelet therapy; it is more commonly related to corticosteroids or certain diabetic medications.
D. Tachycardia is not a common side effect of antiplatelet therapy; cardiovascular effects are usually related to the management of existing conditions.
Correct Answer is A
Explanation
A. A reduced plasma albumin level can lead to increased free drug levels in the bloodstream, raising the risk of drug toxicity, particularly for highly protein-bound medications.
B. Decreased therapeutic effects are less likely because the decrease in albumin can lead to higher free drug concentrations, which may actually increase effects rather than decrease them.
C. Altered drug absorption is generally not directly influenced by plasma albumin levels; it relates more to gastrointestinal factors.
D. Increased drug metabolism is not a direct consequence of lower albumin levels; instead, the concern is primarily about increased free drug concentrations and potential toxicity.