The nurse would contact the health care provider before administering an adrenergic drug to a client who is also taking which drug?
Antibiotic
MAO inhibitor
Diuretic
Analgesic
The Correct Answer is B
A. Antibiotics do not typically interact with adrenergic drugs in a way that would necessitate contacting the healthcare provider before administration.
B. MAO inhibitors can cause significant interactions with adrenergic drugs, potentially leading to hypertensive crises due to increased norepinephrine levels. Therefore, the nurse should contact the healthcare provider to assess the risks before administering an adrenergic agent.
C. Diuretics may affect fluid and electrolyte balance, but they do not pose a direct interaction risk with adrenergic drugs that would require prior consultation with the healthcare provider.
D. Analgesics do not have a significant interaction with adrenergic drugs that would warrant contacting the healthcare provider, as they are used for pain management and can often be safely administered together.
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Correct Answer is D
Explanation
A. Giving the drug with food may delay absorption but does not affect the extent of the first-pass effect.
B. Administering the drug in small, frequent doses may help maintain therapeutic levels but will not significantly alter the first-pass effect.
C. Limiting protein intake could reduce drug binding to proteins, but this is not a standard approach for managing first-pass metabolism.
D. Administering the drug intravenously bypasses the gastrointestinal tract and liver, avoiding the first-pass effect, thereby increasing the amount of free drug available to body cells.
Correct Answer is C
Explanation
A. Hypertension can affect drug distribution to some extent due to altered perfusion but is not the most significant factor impacting distribution, especially for a local condition like cellulitis.
B. Liver dysfunction primarily affects the metabolism and clearance of drugs rather than their distribution, although it may indirectly influence distribution by altering protein binding.
C. Peripheral vascular disease significantly impacts blood flow to the extremities, which can hinder the distribution of the antibiotic to the affected area (the left leg) where the cellulitis is present, leading to reduced drug efficacy.
D. Diverticulitis disease primarily affects the gastrointestinal system and would not directly influence the distribution of an antibiotic used to treat cellulitis in the leg.