The nurse would contact the health care provider before administering an adrenergic drug to a client who is also taking which drug?
Antibiotic
MAO inhibitor
Diuretic
Analgesic
The Correct Answer is B
A. Antibiotics do not typically interact with adrenergic drugs in a way that would necessitate contacting the healthcare provider before administration.
B. MAO inhibitors can cause significant interactions with adrenergic drugs, potentially leading to hypertensive crises due to increased norepinephrine levels. Therefore, the nurse should contact the healthcare provider to assess the risks before administering an adrenergic agent.
C. Diuretics may affect fluid and electrolyte balance, but they do not pose a direct interaction risk with adrenergic drugs that would require prior consultation with the healthcare provider.
D. Analgesics do not have a significant interaction with adrenergic drugs that would warrant contacting the healthcare provider, as they are used for pain management and can often be safely administered together.
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Correct Answer is A
Explanation
A. The combination of nitroglycerin and sildenafil can lead to severe hypotension due to the vasodilatory effects of both medications. This is the most critical adverse reaction the nurse should anticipate.
B. Bradycardia is not a direct effect of this combination; rather, hypotension is a more significant concern.
C. Chest pain may occur if hypotension leads to inadequate perfusion, but it is not a direct adverse effect of the drug interaction.
D. Nausea can occur with various medications, but it is not specifically linked to the interaction between nitroglycerin and sildenafil.
Correct Answer is D
Explanation
A. Giving the drug with food may delay absorption but does not affect the extent of the first-pass effect.
B. Administering the drug in small, frequent doses may help maintain therapeutic levels but will not significantly alter the first-pass effect.
C. Limiting protein intake could reduce drug binding to proteins, but this is not a standard approach for managing first-pass metabolism.
D. Administering the drug intravenously bypasses the gastrointestinal tract and liver, avoiding the first-pass effect, thereby increasing the amount of free drug available to body cells.