The nurse would contact the health care provider before administering an adrenergic drug to a client who is also taking which drug?
Antibiotic
MAO inhibitor
Diuretic
Analgesic
The Correct Answer is B
A. Antibiotics do not typically interact with adrenergic drugs in a way that would necessitate contacting the healthcare provider before administration.
B. MAO inhibitors can cause significant interactions with adrenergic drugs, potentially leading to hypertensive crises due to increased norepinephrine levels. Therefore, the nurse should contact the healthcare provider to assess the risks before administering an adrenergic agent.
C. Diuretics may affect fluid and electrolyte balance, but they do not pose a direct interaction risk with adrenergic drugs that would require prior consultation with the healthcare provider.
D. Analgesics do not have a significant interaction with adrenergic drugs that would warrant contacting the healthcare provider, as they are used for pain management and can often be safely administered together.
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Correct Answer is A
Explanation
A. The combination of nitroglycerin and sildenafil can lead to severe hypotension due to the vasodilatory effects of both medications. This is the most critical adverse reaction the nurse should anticipate.
B. Bradycardia is not a direct effect of this combination; rather, hypotension is a more significant concern.
C. Chest pain may occur if hypotension leads to inadequate perfusion, but it is not a direct adverse effect of the drug interaction.
D. Nausea can occur with various medications, but it is not specifically linked to the interaction between nitroglycerin and sildenafil.
Correct Answer is B
Explanation
A. A drug that binds tightly to protein is typically released slowly, not quickly, as it remains bound in circulation.
B. Tight binding to proteins usually results in a prolonged duration of action since the drug is released gradually into the bloodstream, leading to sustained therapeutic effects.
C. Drugs that bind tightly to protein are generally not excreted quickly; they remain in circulation longer due to the binding.
D. While toxicity can occur with any drug, tight protein binding does not inherently lead to toxicity; it primarily affects the pharmacokinetics of the drug.