The nurse knows the rationale for combination chemotherapy is to:
limit episodes of anticipatory and delayed emesis
lessen the client's risk of developing neutropenia
decrease time intervals between remission
broaden range of cell kill while minimizing toxicities to the client
The Correct Answer is D
A. While limiting emesis is important in cancer treatment, combination chemotherapy primarily focuses on improving efficacy and minimizing toxicities, not specifically targeting nausea and vomiting episodes.
B. Combination chemotherapy can actually increase the risk of neutropenia due to the cumulative effects of multiple agents, as each may independently lower white blood cell counts.
C. Decreasing time intervals between remission is not a primary goal of combination chemotherapy; rather, it aims to achieve better overall treatment outcomes.
D. The main rationale for using combination chemotherapy is to broaden the range of cancer cell kill through different mechanisms of action while minimizing the side effects associated with higher doses of a single agent. This approach can improve treatment efficacy and reduce the likelihood of resistance.
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Correct Answer is C
Explanation
A. Assessing pupils is important, but it provides only partial information about the overall neurologic status and does not give a comprehensive picture of improvement or deterioration.
B. Vital signs can indicate some changes in condition but are not specific to neurologic status and do not provide detailed insight into cognitive or motor function.
C. Performing serial Glasgow Coma Scales allows for a standardized and objective assessment of a patient's level of consciousness, motor responses, and verbal responses over time, making it the most effective method to evaluate neurologic status.
D. The Mini Mental Status Exam provides useful information about cognitive function but may not capture acute changes in neurologic status as effectively as the Glasgow Coma Scale.
Correct Answer is A
Explanation
A. A profound feeling of tiredness is a common side effect of radiation therapy due to fatigue caused by the treatment itself and the body's response to cancer.
B. Renal impairment is not a typical direct side effect of radiation therapy for esophageal cancer; it is more commonly associated with treatments targeting the kidneys or systemic therapies.
C. Expectoration of frothy sputum may indicate pulmonary issues or fluid overload but is not a common side effect specifically related to radiation therapy for esophageal cancer.
D. Development of bone marrow suppression is possible but less common specifically with radiation therapy compared to chemotherapy, which is more directly associated with this side effect.