The nurse is preparing to administer medications to a 54-year-old client. Which medications taken would be affected by the first-pass effect? (Select All that Apply.)
Morphine 2mg IV (Intravenously)
Diphenhydramine (Benadryl) 25mg Tablet
Famotidine 10mg Tablet
Nitroglycerin 4mg Sublingual Tablet
Nitroglycerin 10mg Sublingual Tablet
Acetaminophen 325mg Capsule
Correct Answer : B,C,F
A. Morphine administered intravenously bypasses the gastrointestinal tract and liver, avoiding the first-pass effect entirely.
B. Diphenhydramine in tablet form is absorbed through the gastrointestinal tract and undergoes significant first-pass metabolism in the liver, affecting its bioavailability.
C. Famotidine in tablet form is also subject to first-pass metabolism, which can reduce its effectiveness.
D. Nitroglycerin sublingual tablets are designed to bypass the first-pass metabolism by being absorbed directly into the bloodstream through the mucous membranes.
E. The same applies to nitroglycerin 10mg sublingual tablets; they also avoid the first-pass effect due to sublingual administration.
F. Acetaminophen is taken orally and undergoes first-pass metabolism in the liver, which can significantly affect its overall bioavailability.
Free Nursing Test Bank
- Free Pharmacology Quiz 1
- Free Medical-Surgical Quiz 2
- Free Fundamentals Quiz 3
- Free Maternal-Newborn Quiz 4
- Free Anatomy and Physiology Quiz 5
- Free Obstetrics and Pediatrics Quiz 6
- Free Fluid and Electrolytes Quiz 7
- Free Community Health Quiz 8
- Free Promoting Health across the Lifespan Quiz 9
- Free Multidimensional Care Quiz 10
View Related questions
Correct Answer is B
Explanation
A. Methylprednisolone does not contain soy products and is not contraindicated for clients with a soybean allergy.
B. Ipratropium bromide is often formulated with soy lecithin as a stabilizer, making it contraindicated for individuals allergic to soybeans.
C. Montelukast is a leukotriene receptor antagonist and does not contain soy products, so it is safe for this client.
D. Albuterol does not contain soy products and is generally safe for clients with a soybean allergy.
Correct Answer is A
Explanation
A. Oxytocin is primarily used to induce or augment labor in full-term clients, making this the correct statement regarding its expected outcome.
B. Oxytocin is not used to prevent contractions; it is used to stimulate them, especially during labor.
C. Oxytocin is not a contraceptive; it does not prevent pregnancy but is used in labor management.
D. Oxytocin does not influence egg production; it primarily affects uterine contractions and milk ejection in breastfeeding.