The nurse is caring for a client taking fluoxetine for depression. Which assessment findings indicate that the medication is effective(Select all that apply.)
Improved sleep
Decreased anxiety
Reduced appetite
Weight loss
Correct Answer : A,B,E
A. Improved sleep is correct; an effective antidepressant can help normalize sleep patterns, which is a positive indicator of treatment efficacy.
B. Decreased anxiety is correct; fluoxetine is also effective in treating anxiety symptoms, so a reduction indicates the medication is working.
C. Reduced appetite is incorrect; while some individuals may experience appetite changes, a reduced appetite is not an indicator of effectiveness and could indicate a side effect.
D. Weight loss is incorrect; while weight loss can occur, it is not a definitive measure of the effectiveness of fluoxetine and can also signify side effects.
E. Interest in physical activity is correct; an increase in motivation and engagement in activities is a strong indicator of improvement in depressive symptoms.
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Correct Answer is B
Explanation
A. Prothrombin time (PT) is used to monitor warfarin therapy, not heparin therapy.
B. Activated partial thromboplastin time (aPTT) is the primary laboratory test used to assess the effectiveness of heparin therapy, measuring the time it takes for blood to clot and ensuring therapeutic levels.
C. The International normalized ratio (INR) is also related to warfarin therapy rather than heparin.
D. Serum potassium level is not relevant for assessing heparin therapy but may be monitored for other reasons.
Correct Answer is A
Explanation
A. A reduced plasma albumin level can lead to increased free drug levels in the bloodstream, raising the risk of drug toxicity, particularly for highly protein-bound medications.
B. Decreased therapeutic effects are less likely because the decrease in albumin can lead to higher free drug concentrations, which may actually increase effects rather than decrease them.
C. Altered drug absorption is generally not directly influenced by plasma albumin levels; it relates more to gastrointestinal factors.
D. Increased drug metabolism is not a direct consequence of lower albumin levels; instead, the concern is primarily about increased free drug concentrations and potential toxicity.