The charge nurse is performing an Inservice regarding the adverse effects of antibiotic therapy. Which of the following antibiotics should the nurse include regarding the potential to cause QT prolongation?(Select All that Apply)
Fluoroquinolones
Penicillin's
Macrolides
Beta-Lactams
Cephalosporins
Correct Answer : A,C
A. Fluoroquinolones: Fluoroquinolones, such as ciprofloxacin and levofloxacin, are known to have the potential to prolong the QT interval, increasing the risk of arrhythmias like Torsades de Pointes.
B. Penicillins: Penicillins do not typically cause QT prolongation. Their adverse effects are more likely to include allergic reactions or gastrointestinal disturbances.
C. Macrolides: Macrolides, such as azithromycin and erythromycin, are associated with QT interval prolongation and an increased risk of cardiac arrhythmias.
D. Beta-Lactams: Beta-lactams, which include penicillins and cephalosporins, are not commonly associated with QT prolongation. They are more likely to cause allergic reactions.
E. Cephalosporins: Cephalosporins are not typically associated with QT prolongation. They share a similar beta-lactam structure to penicillins.
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Correct Answer is ["A","C","D","E"]
Explanation
A. Measles: The measles vaccine is a live-attenuated vaccine, which contains a weakened form of the virus and should be avoided in immunocompromised clients due to the risk of infection.
B. Inactivated Polio: The inactivated polio vaccine (IPV) is not a live vaccine, as it uses killed virus, making it safe for immunocompromised clients.
C. Mumps: The mumps vaccine is a live-attenuated vaccine and is part of the MMR (measles, mumps, rubella) vaccine. It should be avoided in clients with weakened immune systems.
D. Varicella: The varicella (chickenpox) vaccine is a live-attenuated vaccine. It should not be given to immunocompromised clients due to the potential risk of severe infection.
E. Rubella: The rubella vaccine is also a live-attenuated vaccine, included in the MMR vaccine, and is contraindicated in immunocompromised individuals.
Correct Answer is A
Explanation
A. Lactic acidosis: Zidovudine has a black box warning for lactic acidosis, a rare but serious complication that can be life-threatening. The nurse should educate the client about symptoms of lactic acidosis, such as muscle pain and weakness.
B. Uterine Cancer: Zidovudine is not associated with uterine cancer.
C. Oral Candidiasis: This is not a black box warning for zidovudine, though oral candidiasis can occur in immunocompromised clients.
D. Thromboembolic Events: This is not a known black box warning for zidovudine.