The charge nurse is performing an Inservice regarding the adverse effects of antibiotic therapy. Which of the following antibiotics should the nurse include regarding the potential to cause QT prolongation?(Select All that Apply)
Fluoroquinolones
Penicillin's
Macrolides
Beta-Lactams
Cephalosporins
Correct Answer : A,C
A. Fluoroquinolones: Fluoroquinolones, such as ciprofloxacin and levofloxacin, are known to have the potential to prolong the QT interval, increasing the risk of arrhythmias like Torsades de Pointes.
B. Penicillins: Penicillins do not typically cause QT prolongation. Their adverse effects are more likely to include allergic reactions or gastrointestinal disturbances.
C. Macrolides: Macrolides, such as azithromycin and erythromycin, are associated with QT interval prolongation and an increased risk of cardiac arrhythmias.
D. Beta-Lactams: Beta-lactams, which include penicillins and cephalosporins, are not commonly associated with QT prolongation. They are more likely to cause allergic reactions.
E. Cephalosporins: Cephalosporins are not typically associated with QT prolongation. They share a similar beta-lactam structure to penicillins.
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Correct Answer is A
Explanation
A. This medication should be taken with a straw to avoid discoloration of the teeth: Liquid forms of iron supplements can stain teeth, so using a straw helps prevent this discoloration.
B. This medication is to be taken at night to prevent constipation from occurring: Iron supplements are better absorbed on an empty stomach or with vitamin C (during the day), not specifically at night. Constipation can still occur regardless of timing.
C. This medication should be taken with antacids to prevent gastrointestinal distress: Antacids interfere with iron absorption and should be avoided.
D. This medication is to be taken with milk to enhance absorption: Milk contains calcium, which can reduce iron absorption. Iron supplements should not be taken with dairy products.
Correct Answer is A
Explanation
A. Lactic acidosis: Zidovudine has a black box warning for lactic acidosis, a rare but serious complication that can be life-threatening. The nurse should educate the client about symptoms of lactic acidosis, such as muscle pain and weakness.
B. Uterine Cancer: Zidovudine is not associated with uterine cancer.
C. Oral Candidiasis: This is not a black box warning for zidovudine, though oral candidiasis can occur in immunocompromised clients.
D. Thromboembolic Events: This is not a known black box warning for zidovudine.