In which stage of the HIV lifecycle does the enzyme integrase play a crucial role, and what is its function in that stage?
Assembly. Integrase packages the viral RNA into new virions.
Integration: Integrase inserts viral DNA into the host's genome.
Entry: Integrase helps the virus fuse with the host cell membrane.
Reverse Transcription: Integrase copies viral RNA into DNA.
The Correct Answer is B
A. In the assembly stage, other proteins and enzymes are involved in the packaging of viral components into new virions, not integrase.
B. During the integration stage, integrase is essential as it inserts the newly formed viral DNA into the host's genome, enabling the virus to utilize the host's cellular machinery for replication.
C. Integrase does not participate in the entry stage; this stage is facilitated by other proteins that aid in the fusion of the virus with the host cell membrane.
D. Integrase is not involved in reverse transcription; that process is facilitated by the enzyme reverse transcriptase, which converts viral RNA into DNA.
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Correct Answer is A
Explanation
A. Binding is the initial step where the HIV virus attaches to the CD4 receptor on the host cell's surface. This interaction is crucial for the subsequent entry of the virus into the host cell.
B. Integration occurs later in the lifecycle, after the virus has entered the host cell and its RNA is converted to DNA.
C. Fusion refers to the process where the viral envelope fuses with the host cell membrane to allow entry into the cell, which follows the binding stage.
D. Reverse Transcription is the process of converting viral RNA into DNA after the virus has entered the host cell, and is not involved in the attachment phase.
Correct Answer is C
Explanation
A. While knowing the location of the assault may be relevant for police reports, it does not directly pertain to the client’s health and potential exposure to HIV.
B. Permission to contact the police is important for legal reasons, but the priority is to address the client's health needs first.
C. Identifying the individual who assaulted the client is critical for assessing the risk of HIV exposure and determining the need for post-exposure prophylaxis (PEP). This question directly impacts the client’s immediate health care.
D. Understanding the day and time of the assault is useful for legal documentation but is less critical than assessing potential exposure to HIV.