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In which stage of the HIV lifecycle does the enzyme integrase play a crucial role, and what is its function in that stage?

A.

Assembly. Integrase packages the viral RNA into new virions.

B.

Integration: Integrase inserts viral DNA into the host's genome.

C.

Entry: Integrase helps the virus fuse with the host cell membrane.

D.

Reverse Transcription: Integrase copies viral RNA into DNA.

Answer and Explanation

The Correct Answer is B

A. In the assembly stage, other proteins and enzymes are involved in the packaging of viral components into new virions, not integrase.  

 

B. During the integration stage, integrase is essential as it inserts the newly formed viral DNA into the host's genome, enabling the virus to utilize the host's cellular machinery for replication.  

 

C. Integrase does not participate in the entry stage; this stage is facilitated by other proteins that aid in the fusion of the virus with the host cell membrane.  

 

D. Integrase is not involved in reverse transcription; that process is facilitated by the enzyme reverse transcriptase, which converts viral RNA into DNA.


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View Related questions

Correct Answer is A

Explanation

A. Stridor is a high-pitched sound indicating upper airway obstruction and is a critical sign of anaphylaxis requiring immediate intervention to secure the airway.

B. Hypotension is a serious condition that occurs during anaphylaxis, but the priority is to address the airway obstruction first.

C. Urticaria (hives) is a common symptom of an allergic reaction but is not life-threatening and can be addressed after more severe symptoms.

D. Vomiting may occur during anaphylaxis but is not the most urgent finding when airway compromise is present.

Correct Answer is A

Explanation

A. Cardiac tamponade is a condition where fluid accumulates in the pericardial space, exerting pressure on the heart and impeding its ability to pump effectively, leading to obstructive shock.

B. Third spacing refers to fluid accumulation in the interstitial spaces but is not a specific diagnosis of obstructive shock.

C. A ruptured aneurysm may lead to hypovolemic shock due to blood loss rather than obstructive shock, which is characterized by physical obstruction to blood flow.

D. Cardiomyopathy is a disease of the heart muscle that affects its ability to pump blood, leading to cardiogenic shock, not obstructive shock.

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