A patient is prescribed metoclopramide for the treatment of gastroparesis. Which of the following is a primary effect of metoclopramide?
Reduces gastric acid secretion
Enhances gastrointestinal motility
Relieves abdominal pain
Acts as an antiemetic by inhibiting serotonin
The Correct Answer is B
A. While metoclopramide may have some effect on gastric acid secretion, its primary role is not to reduce it.
B. Metoclopramide primarily enhances gastrointestinal motility, which helps to facilitate gastric emptying and is especially useful in treating conditions like gastroparesis.
C. Metoclopramide does not specifically relieve abdominal pain; it focuses more on motility and nausea.
D. Although metoclopramide does have antiemetic properties, it primarily acts as a dopamine receptor antagonist rather than directly inhibiting serotonin.
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Correct Answer is D
Explanation
A. Giving the drug with food may delay absorption but does not affect the extent of the first-pass effect.
B. Administering the drug in small, frequent doses may help maintain therapeutic levels but will not significantly alter the first-pass effect.
C. Limiting protein intake could reduce drug binding to proteins, but this is not a standard approach for managing first-pass metabolism.
D. Administering the drug intravenously bypasses the gastrointestinal tract and liver, avoiding the first-pass effect, thereby increasing the amount of free drug available to body cells.
Correct Answer is B
Explanation
A. A drug that binds tightly to protein is typically released slowly, not quickly, as it remains bound in circulation.
B. Tight binding to proteins usually results in a prolonged duration of action since the drug is released gradually into the bloodstream, leading to sustained therapeutic effects.
C. Drugs that bind tightly to protein are generally not excreted quickly; they remain in circulation longer due to the binding.
D. While toxicity can occur with any drug, tight protein binding does not inherently lead to toxicity; it primarily affects the pharmacokinetics of the drug.