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A nurse is teaching a group of nurses about the administration of nitroglycerin. Which of the following routes of administration has the most rapid onset for the client?

A.

Topical ointment

B.

Sublingual

C.

Transdermal patch

D.

Sustained-release

Answer and Explanation

The Correct Answer is B

A. Topical ointment has a slower onset as it must be absorbed through the skin before it can exert its effects.  

 

B. Sublingual nitroglycerin provides rapid relief of angina symptoms because it is absorbed quickly into the bloodstream through the mucous membranes in the mouth, allowing for an immediate effect.  

 

C. Transdermal patches release nitroglycerin slowly over time, leading to a delayed onset of action.  

 

D. Sustained-release formulations are designed for prolonged effects rather than rapid onset, making them slower to take effect compared to sublingual administration.


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Correct Answer is A

Explanation

A. Hypokalemia increases the risk of digoxin toxicity because low potassium levels enhance digoxin's effects on the myocardium. Monitoring and correcting potassium levels is essential in clients on digoxin.

B. Hypophosphatemia is not directly linked to digoxin toxicity and is not a primary concern.

C. Hypocalcemia does not increase the risk of digoxin toxicity; in fact, hypercalcemia would be more concerning in terms of potential toxicity.

D. Hypernatremia does not have a significant effect on digoxin toxicity, so it is not a primary concern when assessing this medication’s safety.

Correct Answer is C

Explanation

A. Grapefruit juice does not have a known interaction with metronidazole and does not need to be avoided.

B. Dairy does not interfere with metronidazole's absorption or effectiveness, so it is not a contraindication.

C. Alcohol should be strictly avoided during and for at least 48 hours after metronidazole treatment, as it can cause a severe reaction, including nausea, vomiting, flushing, and rapid heart rate.

D. Tyramine-based foods do not interact with metronidazole, so they are not a contraindication for this medication.

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