A nurse is teaching a client who is beginning highly active antiretroviral therapy (HAART) for HIV which includes zidovudine. The nurse should include teaching regarding which black box warning associated with this medication?
lactic acidosis
Uterine cancer
oral candidiasis
thromboembolic events
The Correct Answer is A
A. Lactic acidosis: Zidovudine has a black box warning for lactic acidosis, a rare but serious complication that can be life-threatening. The nurse should educate the client about symptoms of lactic acidosis, such as muscle pain and weakness.
B. Uterine Cancer: Zidovudine is not associated with uterine cancer.
C. Oral Candidiasis: This is not a black box warning for zidovudine, though oral candidiasis can occur in immunocompromised clients.
D. Thromboembolic Events: This is not a known black box warning for zidovudine.
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Correct Answer is B
Explanation
A. Clotting Factors: Epoetin alfa does not directly influence clotting factors.
B. Hemoglobin & hematocrit: Epoetin alfa is used to stimulate red blood cell production, which increases hemoglobin and hematocrit levels. Monitoring these values helps determine the drug’s therapeutic effectiveness in improving anemia associated with chronic renal disease.
C. Leukocyte Count: This medication primarily affects red blood cells, not white blood cells (leukocytes).
D. ALT & AST: These are liver function tests and are not related to the therapeutic effect of epoetin alfa.
Correct Answer is C
Explanation
A. Stops fungal growth: Methotrexate is not an antifungal medication. This mechanism of action applies to drugs like azoles or polyenes, which are used to treat fungal infections.
B. Alters pH level: Altering pH is a mechanism used by some antacids or alkalinizing agents, not methotrexate.
C. Inhibits replication by blocking folic acid synthesis: Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, an enzyme involved in folic acid synthesis. This inhibition impairs DNA synthesis, which is crucial in treating leukemia and other cancers.
D. Inhibits helper T cells: This mechanism of action is more closely related to immunosuppressive agents like cyclosporine or tacrolimus, which are used for preventing transplant rejection.