A nurse is caring for a client who is coming to the clinic for human immunodeficiency virus (HIV) testing. The patient's enzyme-linked immunosorbent assay (ELISA) results are positive. Which test will be used to confirm the diagnosis of HIV?
Quantitative RNA assay
Western blot analysis
Viral load test
CD4+ T-cell count
The Correct Answer is B
A. A quantitative RNA assay is used to measure the amount of HIV RNA in the blood and is not used for confirmatory diagnosis after a positive ELISA.
B. The Western blot analysis is the standard confirmatory test for HIV following a positive ELISA result, as it specifically detects the presence of antibodies to HIV proteins.
C. A viral load test assesses the level of virus in the blood but does not confirm the diagnosis of HIV.
D. The CD4+ T-cell count is used to assess immune function in individuals with HIV but is not a confirmatory test for the diagnosis of the virus.
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Correct Answer is A
Explanation
A. Viral load count is the primary test used to assess the effectiveness of HIV therapy by measuring the amount of HIV RNA in the blood, indicating how well the treatment is controlling the virus.
B. The Western blot is used as a confirmatory test for HIV diagnosis rather than monitoring therapy effectiveness.
C. The Enzyme immunoassay (EIA) test is used for initial HIV screening but does not measure viral load or therapy effectiveness.
D. Platelet count can be affected in HIV infection, especially with advanced disease, but it does not directly measure the effectiveness of HIV therapy.
Correct Answer is B
Explanation
A. Distended jugular veins may indicate fluid overload or congestive heart failure, not an allergic reaction.
B. Generalized urticaria, or hives, is a classic sign of an allergic transfusion reaction, presenting as an itchy rash or welts on the skin.
C. Bilateral flank pain is more indicative of a hemolytic reaction, particularly due to kidney involvement, rather than an allergic reaction.
D. A blood pressure of 184/92 mm Hg may suggest hypertension or a reaction, but it is not specific to allergic transfusion reactions, which are characterized by skin symptoms like urticaria.