A nurse is caring for a client who has active pulmonary tuberculosis (TB) and a new prescription for rifampin. The nurse should instruct the client that they should expect which of the following clinical manifestations while taking this medication?
Staining of teeth
Orange colored secretions
Constipation
White-colored stools
The Correct Answer is B
A. Staining of teeth: Rifampin is not known to stain teeth.
B. Orange colored secretions: Rifampin commonly causes orange discoloration of body fluids, including urine, tears, and sweat. This is harmless but can be alarming if the client is not forewarned.
C. Constipation: Constipation is not a typical side effect of rifampin.
D. White-colored stools: Rifampin does not cause white-colored stools, but bile duct obstruction could.
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Correct Answer is ["A","C","D","E"]
Explanation
A. Measles: The measles vaccine is a live-attenuated vaccine, which contains a weakened form of the virus and should be avoided in immunocompromised clients due to the risk of infection.
B. Inactivated Polio: The inactivated polio vaccine (IPV) is not a live vaccine, as it uses killed virus, making it safe for immunocompromised clients.
C. Mumps: The mumps vaccine is a live-attenuated vaccine and is part of the MMR (measles, mumps, rubella) vaccine. It should be avoided in clients with weakened immune systems.
D. Varicella: The varicella (chickenpox) vaccine is a live-attenuated vaccine. It should not be given to immunocompromised clients due to the potential risk of severe infection.
E. Rubella: The rubella vaccine is also a live-attenuated vaccine, included in the MMR vaccine, and is contraindicated in immunocompromised individuals.
Correct Answer is C
Explanation
A. Stops fungal growth: Methotrexate is not an antifungal medication. This mechanism of action applies to drugs like azoles or polyenes, which are used to treat fungal infections.
B. Alters pH level: Altering pH is a mechanism used by some antacids or alkalinizing agents, not methotrexate.
C. Inhibits replication by blocking folic acid synthesis: Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, an enzyme involved in folic acid synthesis. This inhibition impairs DNA synthesis, which is crucial in treating leukemia and other cancers.
D. Inhibits helper T cells: This mechanism of action is more closely related to immunosuppressive agents like cyclosporine or tacrolimus, which are used for preventing transplant rejection.