A nurse is caring for a client receiving febuxostat for long-term treatment of gout. Which of the following adverse effects should the nurse closely monitor for?
Hypertension
Malignant Hyperthermia
Steven's Johnson Syndrome
Renal impairment
The Correct Answer is D
A. Hypertension is not a direct adverse effect of febuxostat; monitoring blood pressure is important but not the primary concern with this medication.
B. Malignant hyperthermia is a rare condition typically associated with certain anesthetic agents and is not related to febuxostat.
C. Steven's Johnson Syndrome is a serious skin reaction that can occur with some medications, but it is not specifically associated with febuxostat.
D. Renal impairment is a known risk with febuxostat, and the nurse should monitor renal function closely, as gout can also be exacerbated by kidney issues and febuxostat is primarily excreted by the kidneys.
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Correct Answer is C
Explanation
A. While liver failure may affect excretion indirectly, it primarily impacts metabolism more significantly.
B. Absorption is typically not directly affected by liver function, though it can be influenced by other factors.
C. The liver is crucial for drug metabolism; chronic liver failure impairs the liver's ability to metabolize medications effectively, leading to potential toxicity.
D. Distribution may be altered due to changes in plasma proteins or blood flow, but the most significant impact occurs in metabolism.
Correct Answer is C
Explanation
A. LABAs can help prevent asthma attacks, including those triggered by exercise, so this statement is accurate and does not indicate a need for further education.
B. LABAs may cause side effects like an increased heart rate, which the client correctly recognizes.
C. LABAs are not intended for immediate relief of asthma symptoms; they are for long-term control. A short-acting beta2-agonist (SABA) should be used for acute symptoms, indicating this client needs further education.
D. Over time, tolerance can develop with some medications, and this understanding is accurate, so it does not indicate a need for additional teaching.