A nurse is caring for a client receiving febuxostat for long-term treatment of gout. Which of the following adverse effects should the nurse closely monitor for?
Hypertension
Malignant Hyperthermia
Steven's Johnson Syndrome
Renal impairment
The Correct Answer is D
A. Hypertension is not a direct adverse effect of febuxostat; monitoring blood pressure is important but not the primary concern with this medication.
B. Malignant hyperthermia is a rare condition typically associated with certain anesthetic agents and is not related to febuxostat.
C. Steven's Johnson Syndrome is a serious skin reaction that can occur with some medications, but it is not specifically associated with febuxostat.
D. Renal impairment is a known risk with febuxostat, and the nurse should monitor renal function closely, as gout can also be exacerbated by kidney issues and febuxostat is primarily excreted by the kidneys.
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Correct Answer is D
Explanation
A. Diabetes Mellitus is not a contraindication for promethazine, although caution may be needed regarding metabolic control.
B. Chronic Kidney Disease does not specifically contraindicate the use of promethazine, but dosage adjustments may be necessary due to altered drug metabolism.
C. Iron Deficiency Anemia does not contraindicate the use of promethazine and would not raise significant concerns for its administration.
D. Narrow-Angle Glaucoma is a contraindication for promethazine due to its anticholinergic properties, which can increase intraocular pressure and worsen glaucoma.
Correct Answer is B
Explanation
A. Topical ointment has a slower onset as it must be absorbed through the skin before it can exert its effects.
B. Sublingual nitroglycerin provides rapid relief of angina symptoms because it is absorbed quickly into the bloodstream through the mucous membranes in the mouth, allowing for an immediate effect.
C. Transdermal patches release nitroglycerin slowly over time, leading to a delayed onset of action.
D. Sustained-release formulations are designed for prolonged effects rather than rapid onset, making them slower to take effect compared to sublingual administration.