A client with a leukemia has been placed on methotrexate. Which of the following mechanism of actions below describes this medication?
Stops fungal growth
Alters pH level
Inhibits replication by blocking folic acid synthesis
Inhibits helper T Cells
The Correct Answer is C
A. Stops fungal growth: Methotrexate is not an antifungal medication. This mechanism of action applies to drugs like azoles or polyenes, which are used to treat fungal infections.
B. Alters pH level: Altering pH is a mechanism used by some antacids or alkalinizing agents, not methotrexate.
C. Inhibits replication by blocking folic acid synthesis: Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, an enzyme involved in folic acid synthesis. This inhibition impairs DNA synthesis, which is crucial in treating leukemia and other cancers.
D. Inhibits helper T cells: This mechanism of action is more closely related to immunosuppressive agents like cyclosporine or tacrolimus, which are used for preventing transplant rejection.
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Correct Answer is B
Explanation
A. Clotting Factors: Epoetin alfa does not directly influence clotting factors.
B. Hemoglobin & hematocrit: Epoetin alfa is used to stimulate red blood cell production, which increases hemoglobin and hematocrit levels. Monitoring these values helps determine the drug’s therapeutic effectiveness in improving anemia associated with chronic renal disease.
C. Leukocyte Count: This medication primarily affects red blood cells, not white blood cells (leukocytes).
D. ALT & AST: These are liver function tests and are not related to the therapeutic effect of epoetin alfa.
Correct Answer is A
Explanation
A. Retinal toxicity: Chloroquine is associated with retinal toxicity, which can lead to vision changes or damage. Regular eye exams are necessary to monitor for early signs of toxicity.
B. Tumors: Chloroquine is not associated with the development of tumors.
C. Pancytopenia: This refers to a reduction in all blood cells and is not a known adverse effect of chloroquine.
D. Cancer: Chloroquine is not linked to an increased risk of cancer.