A client with a leukemia has been placed on methotrexate. Which of the following mechanism of actions below describes this medication?
Stops fungal growth
Alters pH level
Inhibits replication by blocking folic acid synthesis
Inhibits helper T Cells
The Correct Answer is C
A. Stops fungal growth: Methotrexate is not an antifungal medication. This mechanism of action applies to drugs like azoles or polyenes, which are used to treat fungal infections.
B. Alters pH level: Altering pH is a mechanism used by some antacids or alkalinizing agents, not methotrexate.
C. Inhibits replication by blocking folic acid synthesis: Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, an enzyme involved in folic acid synthesis. This inhibition impairs DNA synthesis, which is crucial in treating leukemia and other cancers.
D. Inhibits helper T cells: This mechanism of action is more closely related to immunosuppressive agents like cyclosporine or tacrolimus, which are used for preventing transplant rejection.
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Correct Answer is B
Explanation
A. Thromboembolic events: This is not a black box warning for ciprofloxacin.
B. This drug has a black box warning for causing tendon rupture: Ciprofloxacin, a fluoroquinolone, has a black box warning for the risk of tendonitis and tendon rupture, especially in older adults or those on corticosteroids.
C. Endometrial cancers: Ciprofloxacin is not associated with cancer.
D. Breast cancer: There is no link between ciprofloxacin and breast cancer.
Correct Answer is D
Explanation
A. Regular sun exposure is needed to maximize drug efficacy: This is incorrect; in fact, doxycycline can cause photosensitivity, and sun exposure should be minimized.
B. Avoid water while taking this medication: Water should be taken with doxycycline to help prevent esophageal irritation.
C. Take this medication with antacids to relieve gastrointestinal symptoms: Antacids can also interfere with doxycycline absorption, so they should be avoided.
D. Avoid dairy products when taking this medication: Dairy products can bind to doxycycline and reduce its absorption in the gastrointestinal tract, which decreases its effectiveness. The client should avoid dairy when taking the medication.