A client who is newly diagnosed with metastatic breast cancer is being prepared for chemotherapy. Which of the following adverse effects below should the nurse educate the client regarding chemotherapy?(Select All that Apply.)
Alopecia
Bone marrow suppression
Extrapyramidal symptoms
Bleeding
Nausea
Correct Answer : A,B,D,E
A. Alopecia: Alopecia is a common side effect of chemotherapy because these medications target rapidly dividing cells, including hair follicles.
B. Bone marrow suppression: Chemotherapy can cause bone marrow suppression, leading to decreased production of blood cells, increasing the risk of anemia, infections, and bleeding.
C. Extrapyramidal symptoms: Extrapyramidal symptoms are associated with antipsychotic medications, not chemotherapy. They include symptoms like tremors, rigidity, and bradykinesia.
D. Bleeding: Due to bone marrow suppression, chemotherapy can decrease platelet counts, increasing the risk of bleeding.
E. Nausea: Nausea and vomiting are common adverse effects of chemotherapy due to the irritation of the gastrointestinal lining and activation of the vomiting center in the brain.
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Correct Answer is C
Explanation
A. Stops fungal growth: Methotrexate is not an antifungal medication. This mechanism of action applies to drugs like azoles or polyenes, which are used to treat fungal infections.
B. Alters pH level: Altering pH is a mechanism used by some antacids or alkalinizing agents, not methotrexate.
C. Inhibits replication by blocking folic acid synthesis: Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, an enzyme involved in folic acid synthesis. This inhibition impairs DNA synthesis, which is crucial in treating leukemia and other cancers.
D. Inhibits helper T cells: This mechanism of action is more closely related to immunosuppressive agents like cyclosporine or tacrolimus, which are used for preventing transplant rejection.
Correct Answer is B
Explanation
A. Staining of teeth: Rifampin is not known to stain teeth.
B. Orange colored secretions: Rifampin commonly causes orange discoloration of body fluids, including urine, tears, and sweat. This is harmless but can be alarming if the client is not forewarned.
C. Constipation: Constipation is not a typical side effect of rifampin.
D. White-colored stools: Rifampin does not cause white-colored stools, but bile duct obstruction could.