A client recently diagnosed with Parkinson's Disease is having education reinforced by the nurse. Which of the following medications would the nurse include in the client's education?
paroxetine (Paxil)
lisinopril (Prinivil)
risperidone (Risperdal)
levodopa (Inbrija)
The Correct Answer is D
A. Paroxetine is an SSRI antidepressant used for depression and anxiety disorders, not for Parkinson's Disease.
B. Lisinopril is an ACE inhibitor primarily used for hypertension and heart failure, and it does not address symptoms of Parkinson's Disease.
C. Risperidone is an atypical antipsychotic that may be used in some cases for behavioral symptoms but is not a primary treatment for Parkinson's Disease.
D. Levodopa (Inbrija) is a medication specifically indicated for the management of Parkinson's Disease, as it helps to replenish dopamine levels, alleviating motor symptoms associated with the disease.
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Correct Answer is C
Explanation
A. A history of hypertension is not a direct contraindication for propofol, although it should be monitored as part of overall management.
B. Benzodiazepine abuse/dependence does not contraindicate the use of propofol but may require careful assessment of sedation and anesthesia needs.
C. Propofol contains soy lecithin and egg phosphatide, making allergies to these products a significant contraindication, as they can lead to severe allergic reactions.
D. An allergy to latex is not a contraindication for propofol use but should be addressed in the overall anesthesia plan regarding equipment and supplies.
Correct Answer is B
Explanation
A. A high first-pass effect means that a significant amount of the drug is metabolized by the liver before reaching systemic circulation, making oral administration less effective.
B. Morphine with a high first-pass effect will be more effective when administered via non-enteral routes, such as IV or subcutaneous, to bypass the liver's initial metabolism.
C. The first-pass effect does not influence the kidney’s rate of excretion but rather the liver’s initial metabolism of the drug.
D. The liver, not the kidneys, is responsible for the first-pass metabolism, which occurs before the drug reaches systemic circulation when taken orally.