A client is receiving opioid therapy. The nurse should be alert to the possibility that which could occur if the client receives an opioid agonist-antagonist?
Increased risk for CNS depression
Respiratory depression
Opioid withdrawal symptoms
Hypotension
The Correct Answer is C
A. An increased risk for CNS depression is not typically associated with opioid agonist-antagonists; instead, these medications may produce a ceiling effect on sedation compared to full agonists.
B. Respiratory depression is more commonly associated with full opioid agonists rather than agonist-antagonists. Agonist-antagonists can sometimes counteract respiratory depression caused by full agonists.
C. Opioid withdrawal symptoms can occur when a client who is dependent on full agonist opioids is given an agonist-antagonist, as these medications can displace the agonist from receptors, leading to withdrawal.
D. Hypotension is a possible side effect of opioids but is not a specific concern with the use of agonist-antagonists in the context of opioid therapy.
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Correct Answer is C
Explanation
A. An allergic reaction is a possible response to medication, but it is not directly related to doubling the dosage.
B. Anaphylactic reaction is a severe and rapid allergic response; while possible, it is not the most likely consequence of an overdose in this context.
C. Poisoning is a likely concern when a client takes double the prescribed dosage of analgesics, especially if the medication has a narrow therapeutic index or is known to cause toxicity at high doses.
D. Sedative effects could occur depending on the analgesic used, but poisoning is a more pressing concern following an overdose.
Correct Answer is D
Explanation
A. Nitrates do not share a cross-sensitivity with penicillin and are safe to use in this client.
B. Tetracycline is a different class of antibiotics and does not have cross-sensitivity with penicillin.
C. Aminoglycosides also do not have cross-sensitivity with penicillin and can be safely administered.
D. Cephalosporins are structurally related to penicillin and have a risk of cross-sensitivity; thus, they should not be given to a client with a history of anaphylaxis to penicillin.