A client is experiencing a cholinergic crisis after being administered pyridostigmine IV. The nurse should administer which of the following reversal agents?
Galantamine
Physostigmine
Flumazenil
Atropine
The Correct Answer is D
A. Galantamine is a reversible acetylcholinesterase inhibitor and would not be effective in treating a cholinergic crisis.
B. Physostigmine is also a reversible acetylcholinesterase inhibitor and would not be suitable for reversing a cholinergic crisis.
C. Flumazenil is a benzodiazepine antagonist used to reverse benzodiazepine effects, not cholinergic crises.
D. Atropine is an anticholinergic medication that is effective in reversing the effects of excessive acetylcholine during a cholinergic crisis, making it the appropriate choice in this situation.
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Correct Answer is C
Explanation
A. While liver failure may affect excretion indirectly, it primarily impacts metabolism more significantly.
B. Absorption is typically not directly affected by liver function, though it can be influenced by other factors.
C. The liver is crucial for drug metabolism; chronic liver failure impairs the liver's ability to metabolize medications effectively, leading to potential toxicity.
D. Distribution may be altered due to changes in plasma proteins or blood flow, but the most significant impact occurs in metabolism.
Correct Answer is A
Explanation
A. Estrogen blockers can increase the risk of thromboembolic events, including deep vein thrombosis and pulmonary embolism, which the nurse should caution the client about.
B. Tendon rupture is more commonly associated with certain antibiotics and corticosteroids, not typically with estrogen blockers.
C. Photosensitivity is not a common side effect associated with estrogen blockers; it is more related to specific antibiotics or other medications.
D. While some malignancies can be linked to immunosuppressive therapies, the direct risk of lymphomas is not typically associated with estrogen blockers.