The nurse is caring for a client who has begun to take sertraline (Zoloft) for newly diagnosed depression. Which of the following conditions is associated with an overdose of this medication class?
Tardive Dyskinesia
Serotonin syndrome
Hypertensive Emergency
Extrapyramidal Syndrome
The Correct Answer is B
A. Tardive dyskinesia is primarily associated with long-term use of antipsychotics, not SSRIs like sertraline.
B. Serotonin syndrome is a serious condition that can occur with overdose or interaction of SSRIs, leading to symptoms such as agitation, confusion, rapid heart rate, and increased muscle tone.
C. Hypertensive emergency is not typically associated with SSRIs; it is more related to the use of MAOIs and certain foods.
D. Extrapyramidal syndrome is also primarily linked to antipsychotics rather than SSRIs and would not be a concern with sertraline use.
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Correct Answer is A
Explanation
A. Estrogen blockers can increase the risk of thromboembolic events, including deep vein thrombosis and pulmonary embolism, which the nurse should caution the client about.
B. Tendon rupture is more commonly associated with certain antibiotics and corticosteroids, not typically with estrogen blockers.
C. Photosensitivity is not a common side effect associated with estrogen blockers; it is more related to specific antibiotics or other medications.
D. While some malignancies can be linked to immunosuppressive therapies, the direct risk of lymphomas is not typically associated with estrogen blockers.
Correct Answer is C
Explanation
A. While liver failure may affect excretion indirectly, it primarily impacts metabolism more significantly.
B. Absorption is typically not directly affected by liver function, though it can be influenced by other factors.
C. The liver is crucial for drug metabolism; chronic liver failure impairs the liver's ability to metabolize medications effectively, leading to potential toxicity.
D. Distribution may be altered due to changes in plasma proteins or blood flow, but the most significant impact occurs in metabolism.