A nurse is teaching a class about pharmacodynamics.
The nurse should include that which of the following medication levels occurs when a medication is at the lowest serum concentration?
Toxic.
Peak.
Trough.
Half-life.
The Correct Answer is C
Choice A rationale
Toxic levels refer to concentrations of a medication that are high enough to cause harmful effects or poisoning. This is not related to the lowest serum concentration.
Choice B rationale
Peak levels are the highest concentration of a medication in the bloodstream after administration. This occurs after the drug is absorbed and distributed.
Choice C rationale
Trough levels occur when the medication is at its lowest concentration in the bloodstream, typically just before the next dose is due. Monitoring trough levels helps ensure therapeutic effectiveness while avoiding toxicity.
Choice D rationale
Half-life refers to the time it takes for the concentration of a drug in the bloodstream to decrease by half. It is not directly related to the lowest serum concentration at a specific point in time.
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Correct Answer is B
Explanation
Choice A rationale
Aluminum-containing antacids often cause constipation due to their effect on bowel motility, not diarrhea. They work by neutralizing stomach acid but can lead to decreased bowel movements.
Choice B rationale
Magnesium-containing antacids can cause diarrhea as a side effect. They work by neutralizing stomach acid, and the excess magnesium in the intestines can cause loose stools or diarrhea.
Choice C rationale
Antibiotics can cause diarrhea by disrupting the balance of normal gut bacteria. This disruption can lead to overgrowth of harmful bacteria, such as Clostridium difficile, which can cause diarrhea.
Choice D rationale
Anticholinergics/antispasmodics typically cause constipation rather than diarrhea. They inhibit the parasympathetic nervous system, which slows down gut motility.
Choice E rationale
Opioid narcotics can cause constipation because they slow down the movement of the intestines. They do this by binding to opioid receptors in the gut, which decreases peristalsis.
Correct Answer is C
Explanation
Choice A rationale
Reducing daily activity is not advised for clients with constipation. Physical activity helps stimulate bowel movements and can relieve constipation.
Choice B rationale
Trying to defecate at different times of the day is not recommended. Establishing a regular bowel routine helps promote consistent bowel movements and can prevent constipation.
Choice C rationale
Increasing daily fluid intake is beneficial for constipation. Fluids help soften stool, making it easier to pass and promoting regular bowel movements.
Choice D rationale
Consuming a low-fiber diet is not advisable for clients with constipation. A high-fiber diet helps bulk up and soften stool, making it easier to pass through the intestines.